Permission for what? Entering it, breaking blocks or something like that? Worldguard can do those things. Just search through here (https://worldguard.enginehub.org/en/latest/permissions/) and see if you can find what you need.
If a player don’t have permission he can’t mine it. Such as a. Player has permission mine.1 so he can mine area1.if he has mine.2 so he can mine area2.
Well, you would have to create your region /region define <yourRegion>. Then add the flags you want /region flag <yourRegion> <flag> <allow/deny>. If I remember correctly it is block-break to allow/deny block breaking (see here for all flags). And add the people you want to assign to that area via /region addmember <yourRegion> <member>.
You can use WorldGuard to make regions which require people to have permission to modify those regions. Then use a permissions plugin to apply those permissions to players.
